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The itaconate produced facilitates cytokine production and subsequently activates anti-inflammatory transcription factors, shielding macrophages from infection-induced cell death

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Secondly, it has been shown in culture and in diabetic rats that endothelial cells exhibit a persistence or 'memory' of induced basement membrane mRNA expression long after normalization of high glucose levels, a condition called "glucose memory" [18]

Ohshima, K., Montermini, L., Wells, R.D

diphenyleneiodonium chloride (DPI, Sigma, D2926) at 1 M for 1 h prior to assay (54)

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